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Also, a individual who usually takes ED medication if they’re not enduring ED signs and symptoms will probable not experience any variations, even should they have a substantial dose.
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When the NO/cGMP pathway is activated, as takes place with sexual stimulation, inhibition of PDE5 by sildenafil results in greater corpus cavernosum levels of cGMP . Therefore sexual stimulation is required to ensure that sildenafil to produce its supposed helpful pharmacological results .
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